APHIS 2013 Stakeholder Meeting (March 2013) BSE TSE PRION
Dear Stakeholder,
As we step into 2013, I am very glad that Secretary Vilsack recently
highlighted how USDA resolved dozens of export issues in 2012, and that our
Agency played a key role in these efforts. I am glad, too, that projections tell
us we may be seeing the most successful year yet for U.S. agricultural exports.
This good news follows a banner year in which agricultural exports reached
$135.8 billion—the second highest total on record, and an historic achievement
for our farmers, ranchers, and agribusiness. In fact, the past few years have
been the best for farm exports in our Nation’s history, making America’s
agricultural sector a key contributor to achieving President Obama’s goal under
the National Export Initiative of doubling exports by the end of 2014.
snip...
To prevent the spread of new pests and diseases, APHIS has been cooperating
closely with key international animal and plant standard-setting organizations,
including the World Organization for Animal Health (OIE), the Secretariat of the
International Plant Protection Convention (IPPC), and the North American Plant
Protection Organization (NAPPO). We have contributed to OIE’s goal of ensuring
that science-based standards govern international trade in animals and animal
products by, among other things, publishing a proposed comprehensive rule on
bovine spongiform encephalopathy (BSE) that brings U.S. BSE import regulations
for bovines and bovine products closer in line with OIE standards. We have also
helped refine the criteria for pathogens that must be reported to OIE—an effort
that may lead to delisting certain diseases that some countries have previously
cited as reasons to restrict trade. At the IPPC, we have cooperated on drafting
and adopting international standards for a systems approach for managing risks
associated with fruit flies and for integrated measures related to plants for
planting to ensure safer trade. Our personnel have also helped lead an effort to
improve current methods of setting phytosanitary standards. Within NAPPO, our
negotiators have promoted not only the use of electronic certification, which
expedites the certification process for exports and imports, but also harmonized
approaches to managing trade-related phytosanitary issues.
APHIS values its many stakeholders and is committed to keeping all
interested individuals, groups and organizations informed about relevant Agency
news and information.
Open Letter to Stakeholders: You're invited to the APHIS 2013 Stakeholder
Meeting (March 2013)
Open Letter to Stakeholders: APHIS Trade Accomplishments (February
2013)
Open Letter to Stakeholders: Stakeholder Survey Summary (August 2012)
April 2013 Stakeholder Meeting
Meeting Recording Now Available
Click above to view the closed-caption recording of our April 11th
Stakeholder Meeting. If captions are not visible on your screen, please right
click on the box in the upper right-hand corner of the screen, and click on
"lyrics, captions and subtitles," to turn the captions on.
Meeting Remarks as Prepared for Acting Administrator Kevin Shea
Federal Register Notice: Request for information and notice of stakeholder
meeting
end...tss
Dear Consumer,
you don’t have a chance at the truth, and proper regulation there from,
with the TSE prion disease and the OIE, USDA, or the CFIA.
question ?
of that $135.8 billion—the second highest total on record, banner year, how
much does President Obama plan to use on funding for the TSE prion disease ?
still disgusted in Bacliff, Texas...TSS
Monday, November 30, 2009
USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 ANIMAL HEALTH
CODE
Thursday, December 20, 2012
OIE GROUP RECOMMENDS THAT SCRAPE PRION DISEASE BE DELISTED AND SAME OLD BSe
WITH BOVINE MAD COW DISEASE
those collaborations between the USDA, CFIA, and the OIE, to make these
different TSE prion disease a legal trading commodity will come back to haunt
them, and many others.
PLEASE SEE the documented science that shows this ;
SCRAPIE USA AND CANADA
Highlights of the March 2013 Report
At the end of FY 2012, the percent of cull sheep found positive at
slaughter and adjusted for face color was 0.006 percent. This measure of
prevalence has decreased by 96 percent since slaughter surveillance started in
FY 2003. As of March 31, 2013 this measure of prevalence is 0.006 percent.
Additionally, in FY 2012, 8 new infected or source flocks in seven states
were identified. This represented a 47 percent reduction in the number of new
infected and source flocks identified as compared to FY 2011. To date, two
source flocks and one infected flock have been designated for FY 2013 as of
March 31.
The National Scrapie Eradication Program has determined that radio
frequency identification device (RFID) implants that do not conform to
International Organization for Standardization (ISO) standards may continue to
be used in goats for official ID until March 11, 2014.
For further information about this decision, and for additional important
information about RFID requirements that come into force after March 11, 2015,
please review the “Addendum to the Goat Identification, Visual & Electronic
Power Point Regarding Electronic Implantable Devices” available on the
EradicateScrapie! Web site at
Thursday, March 29, 2012
atypical Nor-98 Scrapie has spread from coast to coast in the USA 2012
NIAA Annual Conference April 11-14, 2011 San Antonio, Texas
Monday, December 1, 2008
When Atypical Scrapie cross species barriers
EVIDENCE OF SCRAPIE IN SHEEP AS A RESULT OF FOOD BORNE EXPOSURE
This is provided by the statistically significant increase in the incidence
of sheep scrape from 1985, as determined from analyses of the submissions made
to VI Centres, and from individual case and flock incident studies. ........
1: J Infect Dis 1980 Aug;142(2):205-8
Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to
nonhuman primates.
Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.
Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of sheep
and goats were transmitted to squirrel monkeys (Saimiri sciureus) that were
exposed to the infectious agents only by their nonforced consumption of known
infectious tissues. The asymptomatic incubation period in the one monkey exposed
to the virus of kuru was 36 months; that in the two monkeys exposed to the virus
of Creutzfeldt-Jakob disease was 23 and 27 months, respectively; and that in the
two monkeys exposed to the virus of scrapie was 25 and 32 months, respectively.
Careful physical examination of the buccal cavities of all of the monkeys failed
to reveal signs or oral lesions. One additional monkey similarly exposed to kuru
has remained asymptomatic during the 39 months that it has been under
observation.
snip...
The successful transmission of kuru, Creutzfeldt-Jakob disease, and scrapie
by natural feeding to squirrel monkeys that we have reported provides further
grounds for concern that scrapie-infected meat may occasionally give rise in
humans to Creutzfeldt-Jakob disease.
PMID: 6997404
12/10/76
AGRICULTURAL RESEARCH COUNCIL REPORT OF THE ADVISORY COMMITTE ON SCRAPIE
Office Note CHAIRMAN: PROFESSOR PETER WILDY
snip...
A The Present Position with respect to Scrapie A] The Problem
Scrapie is a natural disease of sheep and goats. It is a slow and
inexorably progressive degenerative disorder of the nervous system and it ia
fatal. It is enzootic in the United Kingdom but not in all countries.
The field problem has been reviewed by a MAFF working group (ARC 35/77). It
is difficult to assess the incidence in Britain for a variety of reasons but the
disease causes serious financial loss; it is estimated that it cost Swaledale
breeders alone $l.7 M during the five years 1971-1975. A further inestimable
loss arises from the closure of certain export markets, in particular those of
the United States, to British sheep.
It is clear that scrapie in sheep is important commercially and for that
reason alone effective measures to control it should be devised as quickly as
possible.
Recently the question has again been brought up as to whether scrapie is
transmissible to man. This has followed reports that the disease has been
transmitted to primates. One particularly lurid speculation (Gajdusek 1977)
conjectures that the agents of scrapie, kuru, Creutzfeldt-Jakob disease and
transmissible encephalopathy of mink are varieties of a single "virus". The U.S.
Department of Agriculture concluded that it could "no longer justify or permit
scrapie-blood line and scrapie-exposed sheep and goats to be processed for human
or animal food at slaughter or rendering plants" (ARC 84/77)" The problem is
emphasised by the finding that some strains of scrapie produce lesions identical
to the once which characterise the human dementias"
Whether true or not. the hypothesis that these agents might be
transmissible to man raises two considerations. First, the safety of laboratory
personnel requires prompt attention. Second, action such as the "scorched meat"
policy of USDA makes the solution of the acrapie problem urgent if the sheep
industry is not to suffer grievously.
snip...
76/10.12/4.6
Nature. 1972 Mar 10;236(5341):73-4.
Transmission of scrapie to the cynomolgus monkey (Macaca fascicularis).
Gibbs CJ Jr, Gajdusek DC.
Nature 236, 73 - 74 (10 March 1972); doi:10.1038/236073a0
Transmission of Scrapie to the Cynomolgus Monkey (Macaca
fascicularis)
C. J. GIBBS jun. & D. C. GAJDUSEK
National Institute of Neurological Diseases and Stroke, National Institutes
of Health, Bethesda, Maryland
SCRAPIE has been transmitted to the cynomolgus, or crab-eating, monkey
(Macaca fascicularis) with an incubation period of more than 5 yr from the time
of intracerebral inoculation of scrapie-infected mouse brain. The animal
developed a chronic central nervous system degeneration, with ataxia, tremor and
myoclonus with associated severe scrapie-like pathology of intensive astroglial
hypertrophy and proliferation, neuronal vacuolation and status spongiosus of
grey matter. The strain of scrapie virus used was the eighth passage in Swiss
mice (NIH) of a Compton strain of scrapie obtained as ninth intracerebral
passage of the agent in goat brain, from Dr R. L. Chandler (ARC, Compton,
Berkshire).
Epidemiology of Scrapie in the United States 1977
IT'S as obvious as day and night, either Larry, Curley, and Mo have been at
the helm of the USDA/APHIS/FSIS/FDA/CDC/NIH et al for many many years, or the
incompetence of these agencies are so inept, either through ignorance and or
just too overweight with industry reps., they then should be all done away with
and a single agency brought forth, and if not, how will you correct this ongoing
problem ?
Friday, February 11, 2011
Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues
Sunday, December 12, 2010
EFSA reviews BSE/TSE infectivity in small ruminant tissues News Story 2
December 2010
Wednesday, January 18, 2012
Selection of Distinct Strain Phenotypes in Mice Infected by Ovine Natural
Scrapie Isolates Similar to CH1641 Experimental Scrapie
Journal of Neuropathology & Experimental Neurology: February 2012 -
Volume 71 - Issue 2 - p 140–147
Thursday, July 14, 2011
Histopathological Studies of "CH1641-Like" Scrapie Sources Versus Classical
Scrapie and BSE Transmitted to Ovine Transgenic Mice (TgOvPrP4)
Wednesday, January 18, 2012
BSE IN GOATS CAN BE MISTAKEN FOR SCRAPIE
February 1, 2012
Thursday, December 23, 2010
Molecular Typing of Protease-Resistant Prion Protein in Transmissible
Spongiform Encephalopathies of Small Ruminants, France, 2002-2009
Volume 17, Number 1 January 2011
Thursday, November 18, 2010
Increased susceptibility of human-PrP transgenic mice to bovine spongiform
encephalopathy following passage in sheep
Wednesday, February 16, 2011
IN CONFIDENCE
SCRAPIE TRANSMISSION TO CHIMPANZEES
IN CONFIDENCE
why do we not want to do TSE transmission studies on chimpanzees $
snip...
5. A positive result from a chimpanzee challenged severly would likely
create alarm in some circles even if the result could not be interpreted for
man. I have a view that all these agents could be transmitted provided a large
enough dose by appropriate routes was given and the animals kept long enough.
Until the mechanisms of the species barrier are more clearly understood it might
be best to retain that hypothesis.
snip...
R. BRADLEY
STUDIES in Mission Texas of USA sheep scrapie to USA produced a TSE unlike
BSE.
It was, however, performed in the USA in 1979, when it was shown that
cattle inoculated with the scrapie agent endemic in the flock of Suffolk sheep
at the United States Department of Agriculture in Mission, Texas, developed a
TSE quite unlike BSE. 32 The findings of the initial transmission, though not of
the clinical or neurohistological examination, were communicated in October 1988
to Dr Watson, Director of the CVL, following a visit by Dr Wrathall, one of the
project leaders in the Pathology Department of the CVL, to the United States
Department of Agriculture. 33 The results were not published at this point,
since the attempted transmission to mice from the experimental cow brain had
been inconclusive. The results of the clinical and histological differences
between scrapie-affected sheep and cattle were published in 1995. Similar
studies in which cattle were inoculated intracerebrally with scrapie inocula
derived from a number of scrapie-affected sheep of different breeds and from
different States, were carried out at the US National Animal Disease Centre. 34
The results, published in 1994, showed that this source of scrapie agent, though
pathogenic for cattle, did not produce the same clinical signs of brain lesions
characteristic of BSE.
In Confidence - Perceptions of unconventional slow virus diseases of
animals in the USA - APRIL-MAY 1989 - G A H Wells
snip...
PAGE 31
Appendix I
VISIT TO USA - DR A E WRATHALL - INFO ON BSE AND SCRAPIE
1. Dr Clark lately of the Scrapie Research Unit, Mission Texas has
successfully transmitted ovine and caprine scrapie to cattle. The experimental
results have not been published but there are plans to do this. This work was
initiated in 1978. A summary of it is:-
Expt A 6 Her x Jer calves born in 1978 were inoculated as follows with a
2nd Suffolk scrapie passage:-
i/c 1ml i/m, 5ml; s/c 5ml; oral 30ml.
1/6 went down after 48 months with a scrapie/BSE-like disease.
Expt B 6 Her or Jer or HxJ calves were inoculated with angora Goat virus
2/6 went down similarly after 36 months.
Expt C Mice inoculated from brains of calves/cattle in expts A & B were
resistant, only 1/20 going down with scrapie and this was the reason given for
not publishing.
Diagnosis in A, B, C was by histopath. No reports on SAF were given.
Dr Warren Foote indicated success so far in eliminating scrapie in
offspring from experimentally- (and naturally) infected sheep by ET. He had
found difficulty in obtaining emhryos from naturally infected sheep (cf SPA).
3. Prof. A Robertson gave a brief account of BSE. The US approach was to
PAGE 32
accord it a very low profile indeed. Dr A Thiermann showed the picture in
the "Independent" with cattle being incinerated and thought this was a fanatical
incident to be avoided in the US at all costs. BSE was not reported in USA.
4. Scrapie incidents (ie affected flocks) have shown a dramatic increase
since 1978. In 1953 when the National Control Scheme was started there were
10-14 incidents, in 1978 - 1 and in 1988 so far 60.
5. Scrapie agent was reported to have been isolated from a solitary fetus.
6. A western blotting diagnostic technique (? on PrP} shows some promise.
7. Results of a questionnaire sent to 33 states on the subject of the
national sheep scrapie programme survey indicated;
17/33 wished to drop it 6/33 wished to develop it 8/33 had few sheep and
were neutral
Information obtained from Dr Wrathall's notes of a meeting of the U.S.
Animal Health Association at Little Rock, Arkansas Nov. 1988.
please see ;
In Confidence - Perceptions of unconventional slow virus diseases of
animals in the USA - APRIL-MAY 1989 - G A H Wells
ALSO, SEE Scrapie Mission, Texas, did not produce _typical_ BSE...
see page 17 here ;
3.57 The experiment which might have determined whether BSE and scrapie
were caused by the same agent (ie, the feeding of natural scrapie to cattle) was
never undertaken in the UK. It was, however, performed in the USA in 1979, when
it was shown that cattle inoculated with the scrapie agent endemic in the flock
of Suffolk sheep at the United States Department of Agriculture in Mission,
Texas, developed a TSE quite unlike BSE.339 The findings of the initial
transmission, though not of the clinical or neurohistological examination, were
communicated in October 1988 to Dr Watson, Director of the CVL, following a
visit by Dr Wrathall, one of the project leaders in the Pathology Department of
the CVL, to the United States Department of Agriculture.340 The results were not
published at this point, since the attempted transmission to mice from the
experimental cow brain had been inconclusive. The results of the clinical and
histological differences between scrapie-affected sheep and cattle were
published in 1995. Similar studies in which cattle were inoculated
intracerebrally with scrapie inocula derived from a number of scrapie-affected
sheep of different breeds and from different States, were carried out at the US
National Animal Disease Centre.341 The results, published in 1994, showed that
this source of scrapie agent, though pathogenic for cattle, *** did not produce
the same clinical signs of brain lesions characteristic of BSE. ***
WHAT sort of TME surveillance program is in place now, if any???
DO they test for TSE in Mink and what are these figures if so ???
ONE FINAL COMMENT PLEASE, (i know this is long Dr. Freas but please bear
with me) THE USA is in a most unique situation, one of unknown circumstances
with human and animal TSE.
THE USA has the most documented TSE in different species to date, with
substrains growing in those species (BSE/BASE in cattle and CWD in deer and elk,
there is evidence here with different strains), and we know that sheep scrapie
has over 20 strains of the typical scrapie with atypical scrapie documented and
also BSE is very likely to have passed to sheep. all of which have been rendered
and fed back to animals for human and animal consumption, a frightening
scenario. WE do not know the outcome, and to play with human life around the
globe with the very likely TSE tainted blood from the USA, in my opinion is like
playing Russian roulette, of long duration, with potential long and enduring
consequences, of which once done, cannot be undone. These are the facts as i
have come to know through daily and extensive research of TSE over 9 years,
since 12/14/97. I do not pretend to have all the answers, but i do know to
continue to believe in the ukbsenvcjd only theory of transmission to humans of
only this one strain from only this one TSE from only this one part of the
globe, will only lead to further failures, and needless exposure to humans from
all strains of TSE, and possibly many more needless deaths from TSE via a
multitude of proven routes and sources via many studies with primates and
rodents and other species. ...
Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518
SEE ADDITIONAL COMMENTS, WITH SOURCE REFERENCES, IN ATTACHMENT AT BOTTOM OF
PAGE HERE ;
Friday, February 11, 2011
Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues
Monday, April 25, 2011
Experimental Oral Transmission of Atypical Scrapie to Sheep
Volume 17, Number 5-May 2011
Sunday, April 18, 2010
SCRAPIE AND ATYPICAL SCRAPIE TRANSMISSION STUDIES A REVIEW 2010
BOVINE SPONGIFORM ENCEPHALOPATHY BSE USA AND CANADA AKA MAD COW DISEASE
2012 ATYPICAL L-TYPE BASE BSE CONFIRMED CALIFORNIA
Saturday, August 4, 2012
Final Feed Investigation Summary - California BSE Case - July 2012
SUMMARY REPORT CALIFORNIA BOVINE SPONGIFORM ENCEPHALOPATHY CASE
INVESTIGATION JULY 2012
Summary Report BSE 2012
Executive Summary
Saturday, August 4, 2012
Update from APHIS Regarding Release of the Final Report on the BSE
Epidemiological Investigation
Saturday, December 15, 2012
Bovine spongiform encephalopathy: the effect of oral exposure dose on
attack rate and incubation period in cattle -- an update 5 December 2012
Tuesday, March 5, 2013
Use of Materials Derived From Cattle in Human Food and Cosmetics; Reopening
of the Comment Period FDA-2004-N-0188-0051 (TSS SUBMISSION)
FDA believes current regulation protects the public from BSE but reopens
comment period due to new studies
Wednesday, March 20, 2013
GAO-13-244, Mar 18, 2013 Dietary Supplements FDA May Have Opportunities to
Expand Its Use of Reported Health Problems to Oversee Product
From: Terry S. Singeltary Sr.
Sent: Tuesday, March 19, 2013 2:46 PM
To: gomezj@gao.gov
Wednesday, February 20, 2013
World Organization for Animal Health Recommends United States' BSE Risk
Status Be Upgraded
Statement from Agriculture Secretary Tom Vilsack:
Thursday, February 14, 2013
The Many Faces of Mad Cow Disease Bovine Spongiform Encephalopathy BSE and
TSE prion disease
Monday, August 27, 2012
Central Valley Meat Company: USDA Did its Job, OK?
Opinion & Contributed Articles
by Dr. Richard Raymond | Aug 27, 2012 Opinion
Dr. Richard Raymond former Undersecretary for Food Safety, U.S. Department
of Agriculture (2005-2008)
Dr. Richard Raymond former Undersecretary for Food Safety, U.S. Department
of Agriculture (2005-2008) calls out Singeltary
Singeltary rebuttal
If any reader is interested, the transcript of my testimony in front of the
House Subcommittee on Oversight and Investigation of the Committee on Energy and
Commerce, regarding Hallmark/Westland and the Q and A that followed can be seen
online.
In closing, I expect Terry to add his two cents worth and I will point out
that the risk of variant CJD from eating US beef is as close to zero as we can
make it. There are many interlocking steps to keep us safe, including:
snip...see full debate here ;
CFIA investigated for muzzling scientists
Posted Apr. 5th, 2013by Barry WilsonNo Comments
The Canadian Food Inspection Agency is one of seven government departments
and agencies that the federal information commissioner is investigating for
alleged lack of information transparency.
Commissioner Suzanne Legault received a complaint from the University of
Victoria’s Environmental Law Clinic (ELC) and the Ottawa-based advocacy group
Democracy Watch that government muzzling of scientists is a violation of the
Access to Information Act.
The complaint about the CFIA is based on an incident in Calgary late last
year during a briefing on a massive beef recall because of E coli contamination
discovered in product from the XL Foods Inc. plant in Brooks, Alta.
“George Da Pont, president of the CFIA, attended a live news conference to
discuss the government’s handling of the recall and answer questions,” said the
complaint sent to Legault.
“However, the conference was abruptly ended when an assistant of
agriculture minister Gerry Ritz interrupted Da Pont mid-sentence and ushered him
away from the cameras.”
Meagan Murdoch, the minister’s director of communications at the time,
directed Da Pont away from the microphone, abruptly ending a news conference
being televised nationally.
Democracy Watch co-ordinator Tyler Sommers said the Calgary incident is the
only evidence submitted on CFIA information practices.
“The information commissioner may be working on other information as well,
but that is all we submitted,” he said.
The agency issued a statement indicating it is co-operating.
“As Canada’s largest science-based regulator, the CFIA is proud of the
contributions we make to the quality of life of Canadians,” it said.
“The CFIA continuously strives to be transparent and accountable in how it
does business. We will fully cooperate with whatever we are asked to provide
over the course of the investigation.”
Also under investigation are the departments of environment, fisheries and
oceans, national defence, natural resources, treasury board and the National
Research Council of Canada.
In the request for an investigation, the ELC and Democracy Watch accused
the federal government of “systematic efforts to obstruct the right of the
media, and through them the Canadian public, to timely access to government
scientists. There are few issues more fundamental to democracy than the ability
of the public to access scientific information produced by government
scientists, information that their tax dollars have paid for.”
It included a 130-page report, Muzzling Civil Servants: A Threat to
Democracy.
CFIA, USDA, AND OIE SHOOT, SHOVEL, AND SHUT THE HELL UP BSE TSE PRION MAD
COW TYPE POLICY $$$
EDMONTON - Some of former Alberta premier Ralph Klein's most colourful
quotes — and the reactions they elicited:
SNIP...
"This all came about through the discovery of a single, isolated case of
mad cow disease in one Alberta cow on May 20th.
The farmer — I think he was a Louisiana fish farmer who knew nothing about
cattle ranching.
*** I guess any self-respecting rancher would have shot, shovelled and shut
up, but he didn't do that." — Klein recalls how the mad cow crisis started and
rancher Marwyn Peaster's role.
The premier was speaking at the Western Governors Association meeting in
Big Sky, Mont. September 2004.
Wednesday, December 22, 2010
Manitoba veterinarian has been fined $10,000 for falsifying certification
documents for U.S. bound cattle and what about mad cow disease ?
CENSORSHIP IS A TERRIBLE THING $$$
Canada has had a COVER-UP policy of mad cow disease since about the 17th
case OR 18th case of mad cow disease. AFTER THAT, all FOIA request were ignored
$$$
THIS proves there is indeed an epidemic of mad cow disease in North
America, and it has been covered up for years and years, if not for decades, and
it’s getting worse $$$
Thursday, February 10, 2011
TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY REPORT UPDATE CANADA FEBRUARY 2011
and how to hide mad cow disease in Canada Current as of: 2011-01-31
Thursday, January 17, 2013
Canada, U.S. agree on animal-disease measures to protect trade, while
reducing human and animal health protection
Wednesday, August 11, 2010
REPORT ON THE INVESTIGATION OF THE SIXTEENTH CASE OF BOVINE SPONGIFORM
ENCEPHALOPATHY (BSE) IN CANADA
Thursday, August 19, 2010
REPORT ON THE INVESTIGATION OF THE SEVENTEENTH CASE OF BOVINE SPONGIFORM
ENCEPHALOPATHY (BSE) IN CANADA
Friday, March 4, 2011
Alberta dairy cow found with mad cow disease
Increased Atypical Scrapie Detections
Press reports indicate that increased surveillance is catching what
otherwise would have been unreported findings of atypical scrapie in sheep. In
2009, five new cases have been reported in Quebec, Ontario, Alberta, and
Saskatchewan. With the exception of Quebec, all cases have been diagnosed as
being the atypical form found in older animals. Canada encourages producers to
join its voluntary surveillance program in order to gain scrapie-free status.
The World Animal Health will not classify Canada as scrapie-free until no new
cases are reported for seven years. The Canadian Sheep Federation is calling on
the government to fund a wider surveillance program in order to establish the
level of prevalence prior to setting an eradication date. Besides long-term
testing, industry is calling for a compensation program for farmers who report
unusual deaths in their flocks.
another atypical Nor-98 Scrapie case documented in Canada for 2012
Date confirmed Location Animal type infected May 31* Quebec Sheep
Sunday, April 29, 2012
Scrapie confirmed at quarantined sheep farm Canada CFIA
Wednesday, April 4, 2012
20120402 - Breach of quarantine/Violation de la mise en quarantaine of an
ongoing Scrapie investigation
Thursday, February 23, 2012
Atypical Scrapie NOR-98 confirmed Alberta Canada sheep January 2012
Thursday, November 29, 2012
Chronic wasting disease on the Canadian prairies
Thursday, February 14, 2013
Alberta’s first documented case of CWD in a moose was confirmed in January
2013
Tuesday, March 19, 2013
CWD found in wild deer, elk Saskatchewan a slowly spreading epidemic
there'll be no stopping it the longer we wait
Tuesday, April 16, 2013
Cervid Industry Unites To Set Direction for CWD Reform and seem to ignore
their ignorance and denial in their role in spreading Chronic Wasting Disease
The potential impact of prion diseases on human health was greatly
magnified by the recognition that interspecies transfer of BSE to humans by beef
ingestion resulted in vCJD. While changes in animal feed constituents and
slaughter practices appear to have curtailed vCJD, there is concern that CWD of
free-ranging deer and elk in the U.S. might also cross the species barrier.
Thus, consuming venison could be a source of human prion disease. Whether BSE
and CWD represent interspecies scrapie transfer or are newly arisen prion
diseases is unknown. Therefore, the possibility of transmission of prion disease
through other food animals cannot be ruled out. There is evidence that vCJD can
be transmitted through blood transfusion. There is likely a pool of unknown size
of asymptomatic individuals infected with vCJD, and there may be asymptomatic
individuals infected with the CWD equivalent. These circumstances represent a
potential threat to blood, blood products, and plasma supplies.
Friday, November 09, 2012
*** Chronic Wasting Disease CWD in cervidae and transmission to other
species
Sunday, November 11, 2012
*** Susceptibilities of Nonhuman Primates to Chronic Wasting Disease
November 2012
Friday, December 14, 2012
Susceptibility Chronic Wasting Disease (CWD) in wild cervids to Humans 2005
- December 14, 2012
3:00 Afternoon Refreshment Break, Poster and Exhibit Viewing in the Exhibit
Hall
3:30 Transmission of the Italian Atypical BSE (BASE) in Humanized
Mouse
Models Qingzhong Kong, Ph.D., Assistant Professor, Pathology, Case Western
Reserve University
Bovine Amyloid Spongiform Encephalopathy (BASE) is an atypical BSE strain
discovered recently in Italy, and similar or different atypical BSE cases were
also reported in other countries. The infectivity and phenotypes of these
atypical BSE strains in humans are unknown. In collaboration with Pierluigi
Gambetti, as well as Maria Caramelli and her co-workers, we have inoculated
transgenic mice expressing human prion protein with brain homogenates from BASE
or BSE infected cattle. Our data shows that about half of the BASE-inoculated
mice became infected with an average incubation time of about 19 months; in
contrast, none of the BSE-inoculated mice appear to be infected after more than
2 years. ***These results indicate that BASE is transmissible to humans and
suggest that BASE is more virulent than classical BSE in humans.
6:30 Close of Day One
There is a growing number of human CJD cases, and they were presented last
week in San Francisco by Luigi Gambatti(?) from his CJD surveillance
collection.
He estimates that it may be up to 14 or 15 persons which display
selectively SPRPSC and practically no detected RPRPSC proteins.
Monday, October 10, 2011
EFSA Journal 2011 The European Response to BSE: A Success Story
snip...
EFSA and the European Centre for Disease Prevention and Control (ECDC)
recently delivered a scientific opinion on any possible epidemiological or
molecular association between TSEs in animals and humans (EFSA Panel on
Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical
BSE prions as the only TSE agents demonstrated to be zoonotic so far but the
possibility that a small proportion of human cases so far classified as
"sporadic" CJD are of zoonotic origin could not be excluded. Moreover,
transmission experiments to non-human primates suggest that some TSE agents in
addition to Classical BSE prions in cattle (namely L-type Atypical BSE,
Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic
wasting disease (CWD) agents) might have zoonotic potential.
snip...
Thursday, August 12, 2010
Seven main threats for the future linked to prions
First threat
The TSE road map defining the evolution of European policy for protection
against prion diseases is based on a certain numbers of hypotheses some of which
may turn out to be erroneous. In particular, a form of BSE (called atypical
Bovine Spongiform Encephalopathy), recently identified by systematic testing in
aged cattle without clinical signs, may be the origin of classical BSE and thus
potentially constitute a reservoir, which may be impossible to eradicate if a
sporadic origin is confirmed.
***Also, a link is suspected between atypical BSE and some apparently
sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases
constitute an unforeseen first threat that could sharply modify the European
approach to prion diseases.
Second threat
snip...
Friday, November 23, 2012
sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA,
AND CANADA
Sunday, December 2, 2012
CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE
BLEW IT’
Thursday, February 21, 2013
National Prion Disease Pathology Surveillance Center Cases Examined January
16, 2013
16 YEAR OLD SPORADIC FFI ?
Monday, January 14, 2013
Gambetti et al USA Prion Unit change another highly suspect USA mad cow
victim to another fake name i.e. sporadic FFI at age 16 CJD Foundation goes
along with this BSe
Monday, December 31, 2012
Creutzfeldt Jakob Disease and Human TSE Prion Disease in Washington State,
2006–2011-2012
Tuesday, December 25, 2012
CREUTZFELDT JAKOB TSE PRION DISEASE HUMANS END OF YEAR REVIEW DECEMBER 25,
2012
Tuesday, June 26, 2012
Creutzfeldt Jakob Disease Human TSE report update North America, Canada,
Mexico, and USDA PRION UNIT as of May 18, 2012
type determination pending Creutzfeldt Jakob Disease (tdpCJD), is on the
rise in Canada and the USA
Wednesday, June 13, 2012
MEXICO IS UNDER or MIS DIAGNOSING CREUTZFELDT JAKOB DISEASE AND OTHER PRION
DISEASE SOME WITH POSSIBLE nvCJD
*** The discovery of previously unrecognized prion diseases in both humans
and animals (i.e., Nor98 in small ruminants) demonstrates that the range of
prion diseases might be wider than expected and raises crucial questions about
the epidemiology and strain properties of these new forms. We are investigating
this latter issue by molecular and biological comparison of VPSPr, GSS and
Nor98.
VARIABLY PROTEASE-SENSITVE PRIONOPATHY IS TRANSMISSIBLE ...price of prion
poker goes up again $
OR-10: Variably protease-sensitive prionopathy is transmissible in bank
voles
Romolo Nonno,1 Michele Di Bari,1 Laura Pirisinu,1 Claudia D’Agostino,1
Stefano Marcon,1 Geraldina Riccardi,1 Gabriele Vaccari,1 Piero Parchi,2 Wenquan
Zou,3 Pierluigi Gambetti,3 Umberto Agrimi1 1Istituto Superiore di Sanità; Rome,
Italy; 2Dipartimento di Scienze Neurologiche, Università di Bologna; Bologna,
Italy; 3Case Western Reserve University; Cleveland, OH USA
Background. Variably protease-sensitive prionopathy (VPSPr) is a recently
described “sporadic”neurodegenerative disease involving prion protein
aggregation, which has clinical similarities with non-Alzheimer dementias, such
as fronto-temporal dementia. Currently, 30 cases of VPSPr have been reported in
Europe and USA, of which 19 cases were homozygous for valine at codon 129 of the
prion protein (VV), 8 were MV and 3 were MM. A distinctive feature of VPSPr is
the electrophoretic pattern of PrPSc after digestion with proteinase K (PK).
After PK-treatment, PrP from VPSPr forms a ladder-like electrophoretic pattern
similar to that described in GSS cases. The clinical and pathological features
of VPSPr raised the question of the correct classification of VPSPr among prion
diseases or other forms of neurodegenerative disorders. Here we report
preliminary data on the transmissibility and pathological features of VPSPr
cases in bank voles.
Materials and Methods. Seven VPSPr cases were inoculated in two genetic
lines of bank voles, carrying either methionine or isoleucine at codon 109 of
the prion protein (named BvM109 and BvI109, respectively). Among the VPSPr cases
selected, 2 were VV at PrP codon 129, 3 were MV and 2 were MM. Clinical
diagnosis in voles was confirmed by brain pathological assessment and western
blot for PK-resistant PrPSc (PrPres) with mAbs SAF32, SAF84, 12B2 and 9A2.
Results. To date, 2 VPSPr cases (1 MV and 1 MM) gave positive transmission
in BvM109. Overall, 3 voles were positive with survival time between 290 and 588
d post inoculation (d.p.i.). All positive voles accumulated PrPres in the form
of the typical PrP27–30, which was indistinguishable to that previously observed
in BvM109 inoculated with sCJDMM1 cases.
In BvI109, 3 VPSPr cases (2 VV and 1 MM) showed positive transmission until
now. Overall, 5 voles were positive with survival time between 281 and 596
d.p.i.. In contrast to what observed in BvM109, all BvI109 showed a GSS-like
PrPSc electrophoretic pattern, characterized by low molecular weight PrPres.
These PrPres fragments were positive with mAb 9A2 and 12B2, while being negative
with SAF32 and SAF84, suggesting that they are cleaved at both the C-terminus
and the N-terminus. Second passages are in progress from these first successful
transmissions.
Conclusions. Preliminary results from transmission studies in bank voles
strongly support the notion that VPSPr is a transmissible prion disease.
Interestingly, VPSPr undergoes divergent evolution in the two genetic lines of
voles, with sCJD-like features in BvM109 and GSS-like properties in BvI109.
The discovery of previously unrecognized prion diseases in both humans and
animals (i.e., Nor98 in small ruminants) demonstrates that the range of prion
diseases might be wider than expected and raises crucial questions about the
epidemiology and strain properties of these new forms. We are investigating this
latter issue by molecular and biological comparison of VPSPr, GSS and Nor98.
Wednesday, March 28, 2012
VARIABLY PROTEASE-SENSITVE PRIONOPATHY IS TRANSMISSIBLE, price of prion
poker goes up again $
Sunday, March 31, 2013
Creutzfeldt Jakob Disease CJD worlds youngest documented victim, 11 years
old, shall we pray
Monday, April 15, 2013
Dr. Stephen B. Thacker Director Centers for Disease Control and
Prevention′s Office of Science, Epidemiology and Laboratory Services (OSELS)
dies from Creutzfeldt Jakob Disease CJD
IT is of my opinion, that the OIE and the USDA et al, are the soul reason,
and responsible parties, for Transmissible Spongiform Encephalopathy TSE prion
diseases, including typical and atypical BSE, typical and atypical Scrapie, and
all strains of CWD, and human TSE there from, spreading around the globe.
I have lost all confidence of this organization as a regulatory authority
on animal disease, and consider it nothing more than a National Trading
Brokerage for all strains of animal TSE, just to satisfy there commodity. AS i
said before, OIE should hang up there jock strap now, since it appears they will
buckle every time a country makes some political hay about trade protocol,
commodities and futures. IF they are not going to be science based, they should
do everyone a favor and dissolve there organization.
JUST because of low documented human body count with nvCJD and the long
incubation periods, the lack of sound science being replaced by political and
corporate science in relations with the fact that science has now linked some
sporadic CJD with atypical BSE and atypical scrapie, and the very real threat of
CWD being zoonosis, I believed the O.I.E. has failed terribly and again, I call
for this organization to be dissolved. ...
A_Annex_VII_A_AHG_Report_Meeting_Final
Scrapie – The disease does not show significant morbidity (2-30%
within-flock morbidity) or mortality and is not zoonotic. However, the Group
noted the difficulty in evaluating the level of morbidity for diseases with a
long incubation period such as scrapie. The Group recommended that the disease
be delisted.
Chapter 1.6.
PROCEDURES FOR SELF DECLARATION AND FOR OFFICIAL RECOGNITION BY the
OIE
Article 1.6.1.
[No change]
Article 1.6.2.
[No change]
Article 1.6.3.
Questionnaire on bovine spongiform encephalopathy
SNIP...
Article 11.5.29.
Conclusions of the risk assessment
The overall risk of BSE in the cattle population of a country or zone is
proportional to the level of known or potential exposure to BSE infectivity and
the potential for recycling and amplification of the infectivity through
livestock feeding practices. For the risk assessment to conclude that the cattle
population of a country or zone is free from BSE risk, it should have
demonstrated that appropriate measures have been taken to manage any risks
identified.
BOUGHT AND PAID FOR BY YOUR LOCAL CATTLE DEALERS AND LOBBYIEST
EVERYWHERE...
IN A NUT SHELL ;
(Adopted by the International Committee of the OIE on 23 May 2006)
11. Information published by the OIE is derived from appropriate
declarations made by the official Veterinary Services of Member Countries. The
OIE is not responsible for inaccurate publication of country disease status
based on inaccurate information or changes in epidemiological status or other
significant events that were not promptly reported to the Central Bureau,
i pulled this comment off another board about the OIE and all it's lobby
groups...tss
Having been to their offices in Paris and talked personally with the Head
of the Animal Test Section, you would choke if you knew how many lobby groups
attend that office daily. There is a steady stream of paid lobby groups that
have one goal in life and that is to sway the Section Heads of each department
within the OIE to suit the needs of different juristictions around the world,
which curiously enough, also includes the USA and Canada. Anyone can go there
and chat with them - providing they can privide valid cause to be let in. To say
that the only goal of the OIE is animal health is actually only part of their
function. They are more than that and my discussions with Dr. Diaz there has
showed me that. But to blindly make a statement regarding what they do when you
have no idea what they actually do is like eating the skin of the orange and not
knowing what is actually under. Interstingly you state that the US Government
applied pressure (to the OIE) I assume and that is a great example of the lobby
groups doing their job. So, at the end of the day, one can safely assume that it
is the pressure applied by certain influential lobby groups that will determine
a likely aoutcome to an apparent OIE directive. Man alive, isn't it great to
live in a democracy wherein the people get to make the choices and not just some
"other" interested party or group - say like........Cargyll or Tyson for
example?
So, one last question, question?
Who wags the tail of that dog?? And for what reason other than one that is
purely associated with trade and international agreements and greed?
Location: Edmonton, Alberta, Canada
Occupation: CEO of BSE Prion Solutions Inc.
Interests: Prion Diseases and Live Animal Testing
end...tss
Tuesday, July 17, 2012
O.I.E. BSE, CWD, SCRAPIE, TSE PRION DISEASE Final Report of the 80th
General Session, 20 - 25 May 2012
Wednesday, May 25, 2011
O.I.E. Terrestrial Animal Health Standards Commission and prion (TSE)
disease reporting 2011
----- Original Message -----
From: Terry S. Singeltary Sr.
To: BSE-L@LISTS.AEGEE.ORG
Cc: trade@oie.int ; oie@oie.int ; f.diaz@oie.int ; scientific.dept@oie.int
; cjdvoice@yahoogroups.com ; BLOODCJD@YAHOOGROUPS.COM
Sent: Tuesday, May 24, 2011 2:24 PM
Subject: O.I.E. Terrestrial Animal Health Standards Commission and prion
(TSE) disease reporting 2011
Saturday, December 18, 2010
OIE Global Conference on Wildlife Animal Health and Biodiversity -
Preparing for the Future (TSE AND PRIONS) Paris (France), 23-25 February 2011
Monday, November 23, 2009
BSE GBR RISK ASSESSMENTS UPDATE NOVEMBER 23, 2009 COMMISSION OF THE
EUROPEAN COMMUNITIES AND O.I.E. COMMISSION DECISION of 11 November 2009 amending
the Annex to Decision 2007/453/EC as regards the BSE status of Chile, Colombia
and Japan (notified under document C(2009) 8590)
Tuesday, January 1, 2008
BSE OIE USDA
Subject: OIE BSE RECOMMENDATION FOR USA, bought and paid for by your local
cattle dealers i.e. USDA
Date: May 14, 2007 at 9:00 am PST
OIE BSE RECOMMENDATION FOR USA, bought and paid for by your local cattle
dealers i.e. USDA
STATEMENT BY DR. RON DEHAVEN REGARDING OIE RISK RECOMMENDATION
March 9, 2007
Tuesday, November 02, 2010
IN CONFIDENCE
The information contained herein should not be disseminated further except
on the basis of "NEED TO KNOW".
BSE - ATYPICAL LESION DISTRIBUTION (RBSE 92-21367) statutory (obex only)
diagnostic criteria CVL 1992
2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006
Comments on technical aspects of the risk assessment were then submitted to
FSIS.
Comments were received from Food and Water Watch, Food Animal Concerns
Trust (FACT), Farm Sanctuary, R-CALF USA, Linda A Detwiler, and Terry S.
Singeltary.
This document provides itemized replies to the public comments received on
the 2005 updated Harvard BSE risk assessment. Please bear the following points
in mind:
Owens, Julie
From: Terry S. Singeltary Sr. [flounder9@verizon.net]
Sent: Monday, July 24, 2006 1:09 PM
To: FSIS RegulationsComments
Subject: [Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine
Spongiform Encephalopathy (BSE)
Page 1 of 98
FSIS, USDA, REPLY TO SINGELTARY
U.S.A. 50 STATE BSE MAD COW CONFERENCE CALL Jan. 9, 2001
TSS
