UNITED STATES HOUSE OF REPRESENTATIVES ROSA L. DeLAURO COMMITTEE ON
APPROPRIATIONS 3rd District, Connecticut
June 13,2014
The Honorable Mr. Brian Ronholm Acting Under Secretary for Food Safety U.S.
Department of Agriculture 1400 Independence Ave.•SW Washington, DC
20250-3700
Dear Acting Under Secretary Ronholm,
I am deeply troubled by yesterday's news of the Fruitland American Meat
establishment's recall of approximately 4,012 pounds of fresh beef products
because of a potential risk for Bovine Spongiform Encephalopathy (BSE), also
referred to as mad cow disease. This potentially tainted beef, "Rain Crow Ranch
Ribeye," went to a Whole Foods distribution center in Connecticut that serves
stores in New England and to two restaurants, one in New York City and one in
Kansas City, Missouri.
My understanding is that the potentially tainted meat was not processed
correctly for the age of these animals, resulting in parts of the nervous system
that may not have been completely removed, which is not compliant with agency
regulations that require their removal in cattle 30 months of age and
older.
According to the FSIS news release the affected product was produced
between September 5, 2013 through April 24, 2014. On the heels of all these
other massive recalls, e.g. Wolverine, EI Rancho, etc., which also involved
products produced over a long period of time, I question why it took ten months
for this error to be discovered. Was this a matter of inadequate staffing
levels, poor training, negligence, or some other reason? I want to learn
more.
In view of this concern, I am requesting a briefing from you before June
27th, so that we can discuss these issues in depth. I look forward to meeting
with you shortly.
Sincerely,
Rosa L. DeLauro Member of Congress
Greetings Honorable Rep. Rosa DeLauro Ma’am (D-CT) et al,
I wish to give you the information you requested above, but I will tell you
now, nothing, NOTHING will happen. but thanks for trying anyway.
My mother and many more here in North America have been murdered by what I
call corporate and political homicide, i.e. mad cow disease. she died from hvCJD
i.e. the Heidenhain Variant of Creutzfeldt Jakob disease, and exceedingly rare
strain of what officials call sporadic CJD. but what officials DON’t or WANT
tell you, is that some cases of sporadic CJD have been linked to atypical BSE,
and c-BSE i.e. typical UK type BSE, this will also propagate as sporadic CJD.
this UKBSEnvCJD only theory is crap Ma’am, and proven to be so for trade
purposes. I will not even get into mad deer disease aka CWD and risk factors
there from here.
These SRM breaches, MBM mad cow feed breaches, BSE mad cow testing
Breaches, Surveillance failures have happened time and time and time again over
the past 16 years or so, and time and time again an official will raise
awareness, and nothing happens. The GAO or the OIG issues warnings about these
mad cow breaches, and NOTHING, nada. nothing will happen this time. For Gods
sake, the USDA NSLP fed our children dead stock downer cows for 4 years, the
most high risk for BSE TSE prion disease, before doing anything about it. I lost
my mother to the hvCJD, confirmed, back in 1997, have watched and followed
closely the USDA inc. mad cow follies over the past 16 years, and nothing has
changed, except the administrations. we now have a human mad cow case now in
Texas that the Government is covering up at all cost. the government refuses to
issue any information on this case, except that the person traveled overseas, so
it’s a foreign animal disease the man contracted...NOT!
fact is, BSE cases in Europe of the past years have dropped dramatically
due to feed ban that was enforced, and extensive BSE testing, in large numbers.
just the opposite has happened in the USA. it’s all been documented. there is
ample evidence that there is as much of a chance (if not more), that this victim
contracted human mad cow disease from sources right here in the USA. this PR
push to alienate a USA source factor for human BSE in the USA is a PR stunt by
the USDA inc., and not justified now, in my opinion. compare BSE testing figures
in the EU compared to the USA, compare mad cow feed ban breaches, and you will
see. hell, the 2004 enhanced BSE surveillance program was flawed so bad, the top
Prion God at the NIH TSE prion expert Paul Brown, says he does not trust
anything from the USDA since Texas covered up a mad cow for 7 months, on a 48
hour confirmation turn around. it’s all documented below in link. USDA inc shut
down the mad cow testing after so many atypical BSE cases started showing up.
yes, another foreigner comes to the USA, or another USA citizens does some
traveling, and all of a sudden, it’s a foreign disease. evidently, these folks
never eat anything in the USA, and contracts nvcjd. right. just like the last
one in 2005. really? here are the facts of the TEXAS MAD COW, MAD COW FEED in
Texas, CJD CLUSTER in Texas, CJD CASE IN 38 YEAR OLD WOMAN THAT APPARENTLY
WORKED ON THE SLAUGHTER LINE FOR TYSON in Texas, AND OTHER STRANGE TSE PRION
DISEASE IN VERY YOUNG VICTIMS HERE IN TEXAS with long duration of illness from
onset of clinical symptoms to death, CALLED SPORADIC FFI (except it is not
linked to any genetic make up of that family), another nvcjd victim back in 2005
in Texas, apparently another UK victim that had moved to Texas, and never ate
anything. these are the facts as I have come to know them (official documents),
since hvcjd took my mom in December of 1997. just made a promise to mom, never
forget, and never let them forget, the rest of the story, the truth you don’t
hear about. ...our fine federal friends and the USDA inc, has lied to all of
us...
HUMAN BSE NVCJD CASE IN TEXAS, COVER UP CONTINUES AS OF JUNE 14,
2014...TSS
Monday, June 02, 2014
*** Confirmed Human BSE aka mad cow Variant CJD vCJD or nvCJD Case in Texas
Monday, June 9, 2014
*** TEXAS MAD COW COVER UP (human BSE) AGAIN IN TEXAS, Mr. President Sir,
we need your help please
Governor Rick Perry has done everything he can to cover up mad cow disease
and human TSE prion disease there from in Texas over the last 15 years or so. We
have another nvCJD case here in Texas i.e. human BSE, still no information there
from, another lame excuse, typical though, and more junk science, we need help
Mr. President...
Thursday, June 12, 2014
Missouri Firm Recalls Ribeye and Carcass Products That May Contain
Specified Risk Materials 4,012 pounds of fresh beef products because the dorsal
root ganglia may not have been completely removed
>>> FSIS and Fruitland American Meat have received no reports of
adverse reactions due to consumption of these products.
>>> The USDA says there's no indication that the slaughtered
cattle showed signs of BSE.
ha, ha, ha !
what a hoot.
our fine federal friends think we are all idiots. well, most of the lay
public is oblivious to the science behind the TSE prion aka mad cow type
disease.
SO, every time you here the FSIS, the USDA, the APHIS, or the FDA say that,
‘’NO REPORTED ILLNESS TO DATE’’, and or ‘’USDA says there's no indication that
the slaughtered cattle showed signs of BSE’’, they are in fact calling every one
of us idiots.
sadly, most of us go with the flow...and the industry keeps feeding us
SRMs, and the government keeps telling us it’s all sporadic CJD.
and the world is happy $$$
the incubation period for the BSE CJD TSE prion is in YEARS TO DECADES.
SUB-CLINICAL INFECTION IS A MAJOR RISK FACTOR !!!
Evidence of subclinical prion disease in aged mice following exposure to
bovine spongiform encephalopathy
Karen L. Brown and Neil A. Mabbott
+ Author Affiliations The Roslin Institute and Royal (Dick) School of
Veterinary Sciences, University of Edinburgh, Edinburgh, UK Correspondence Neil
A. Mabbott neil.mabbott@roslin.ed.ac.uk Received 5 September 2013. Accepted 6
October 2013.
Abstract
The occurrence of variant Creutzfeldt–Jakob (vCJD) disease in humans was
almost certainly the result of consumption of food contaminated with bovine
spongiform encephalopathy (BSE) prions. Despite probable widespread exposure of
the UK population to BSE-contaminated food in the 1980s, vCJD has been
identified predominantly in young individuals, and there have been fewer cases
of clinical disease than anticipated. The reasons for this are uncertain.
Following peripheral exposure, many prions replicate within the lymphoid tissues
before infecting the central nervous system. We have shown that the effects of
host age on the microarchitecture of the spleen significantly impair
susceptibility to mouse-adapted prions after peripheral exposure. The
transmission of prions between different mammalian species is considered to be
limited by the ‘species barrier’, which is dependent on several factors,
including an intact immune system. Thus, cross-species prion transmission may be
much less efficient in aged individuals. To test this hypothesis, we compared
prion pathogenesis in groups of young (6–8 weeks old) and aged (600 days old)
mice injected with primary BSE brain homogenate. We showed that prion
pathogenesis was impaired dramatically in aged mice when compared with young
animals. Whereas most young mice succumbed to clinical prion disease, all aged
mice failed to develop clinical disease during their lifespans.
*** However, the demonstration that prion accumulation was detected in the
lymphoid tissues of some aged mice after injection with primary BSE brain
homogenate, in the absence of clinical signs of prion disease, has important
implications for human health.
*** In some cases, the incubation period may be as long as 50 years
At a hearing in Parliament last Wednesday, the Science and Technology
Committee was told that vCJD continued to pose a “significant” risk to UK public
health and that more than one in every 2000 people could be silent carriers of
the disease.
*** vCJD can have an incubation period of over 30 years.
Monday, February 03, 2014
CREUTZFELDT-JAKOB DISEASE T.S.E. PRION U.K. UPDATE As at 3rd February 2014
***In addition, non-human primates are specifically susceptible for
atypical BSE as demonstrated by an approximately 50% shortened incubation time
for L-type BSE as compared to C-type. Considering the current scientific
information available, it cannot be assumed that these different BSE types pose
the same human health risks as C-type BSE or that these risks are mitigated by
the same protective measures.
Hence, the data presented here are important for a risk- based SRM
definition.
Competing interests
The authors declare that they have no competing interests.
see much more here ; Saturday, December 21, 2013
Complementary studies detecting classical bovine spongiform encephalopathy
infectivity in jejunum, ileum and ileocaecal junction in incubating cattle
Friday, March 21, 2014
Rancho Dead Stock Cancer Downers Recall Explained FSIS March 20 2014
?
“As of March 20, 2014, FSIS has completed all checks (effectiveness checks
and disposition verification checks) for recalls 002-2014 and 013-2014 regarding
Rancho Feeding Corporation. FSIS has determined that based on the number of
successful checks (see Directive 8080.1, Attachment 1, Table 3) where businesses
were notified of the recall and removed affected products from commerce that the
recall activities were effective.”
hmmm ???
Thursday, November 28, 2013
Department of Justice Former Suppliers of Beef to National School Lunch
Program Settle Allegations of Improper Practices and Mistreating Cows
*** seems USDA NSLP et al thought that it would be alright, to feed our
children all across the USA, via the NSLP, DEAD STOCK DOWNER COWS, the most high
risk cattle for mad cow type disease, and other dangerous pathogens, and they
did this for 4 years, that was documented, then hid what they did by having a
recall, one of the largest recalls ever, and they made this recall and masked
the reason for the recall due to animal abuse (I do not condone animal abuse),
not for the reason of the potential for these animals to have mad cow BSE type
disease (or other dangerous and deadly pathogens). these TSE prion disease can
lay dormant for 5, 10, 20 years, or longer, WHO WILL WATCH OUR CHILDREN FOR THE
NEXT 5 DECADES FOR CJD ???
Saturday, September 21, 2013
Westland/Hallmark: 2008 Beef Recall A Case Study by The Food Industry
Center January 2010 THE FLIM-FLAM REPORT
DID YOUR CHILD CONSUME SOME OF THESE DEAD STOCK DOWNER COWS, THE MOST HIGH
RISK FOR MAD COW DISEASE ??? this recall was not for the welfare of the animals.
...tss you can check and see here ; (link now dead, does not work...tss)
try this link ;
FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED
VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2013 UPDATE
OAI 2012-2013
OAI (Official Action Indicated) when inspectors find significant
objectionable conditions or practices and believe that regulatory sanctions are
warranted to address the establishment’s lack of compliance with the regulation.
An example of an OAI classification would be findings of manufacturing
procedures insufficient to ensure that ruminant feed is not contaminated with
prohibited material. Inspectors will promptly re-inspect facilities classified
OAI after regulatory sanctions have been applied to determine whether the
corrective actions are adequate to address the objectionable conditions.
ATL-DO 1035703 Newberry Feed & Farm Ctr, Inc. 2431 Vincent St.
Newberry SC 29108-0714 OPR DR, FL, FR, TH HP 9/9/2013 OAI Y
DET-DO 1824979 Hubbard Feeds, Inc. 135 Main, P.O. Box 156 Shipshewana IN
46565-0156 OPR DR, FL, OF DP 8/29/2013 OAI Y
ATL-DO 3001460882 Talley Farms Feed Mill Inc 6309 Talley Rd Stanfield NC
28163-7617 OPR FL, TH NP 7/17/2013 OAI N
NYK-DO 3010260624 Sherry Sammons 612 Stoner Trail Rd Fonda NY 12068-5007
OPR FR, OF NP 7/16/2013 OAI Y
DEN-DO 3008575486 Rocky Ford Pet Foods 21693 Highway 50 East Rocky Ford CO
81067 OPR RE, TH HP 2/27/2013 OAI N
CHI-DO 3007091297 Rancho Cantera 2866 N Sunnyside Rd Kent IL 61044-9605
OPR FR, OF HP 11/26/2012 OAI Y
*** DEN-DO 1713202 Weld County Bi Products, Inc. 1138 N 11th Ave Greeley
CO 80631-9501 OPR RE, TH HP 10/12/2012 OAI N
Ruminant Feed Inspections Firms Inventory (excel format)
PLEASE NOTE, the VAI violations were so numerous, and unorganized in dates
posted, as in numerical order, you will have to sift through them for
yourselves. ...tss
Tuesday, June 11, 2013
*** Weld County Bi-Products dba Fort Morgan Pet Foods 6/1/12 significant
deviations from requirements in FDA regulations that are intended to reduce the
risk of bovine spongiform encephalopathy (BSE) within the United States
Thursday, June 6, 2013
BSE TSE PRION USDA FDA MAD COW FEED COMPLIANCE REPORT and NAI, OAI, and
VAI ratings as at June 5, 2013
Greetings,
since our fine federal friends have decided not to give out any more
reports on the USA breaches of the feed ban and surveillance etc. for the BSE
TSE prion mad cow type disease in the USDA livestock, I thought I might attempt
it. I swear, I just don’t understand the logic of the SSS policy, and that
includes all of it. I assure you, it would be much easier, and probably better
for the FDA and the USDA INC., if they would simply put some kind of report out
for Pete’s sake, instead of me doing it after I get mad, because I am going to
put it all out there. the truth.
PLEASE BE ADVISED, any breach of any of the above classifications OAI,
VAI, RTS, CAN lead to breaches into the feed BSE TSE prion protocols, and CAN
lead to the eventual suspect tainted feed reaching livestock. please, if any
USDA official out there disputes this, please explain then how they could not.
paperwork errors can eventually lead to breaches of the BSE TSE prion mad cow
feed ban reaching livestock, or contamination and exposure there from, as well.
I would sure like to see the full reports of just these ;
4018 CHI-DO 3007091297 Rancho Cantera 2866 N Sunnyside Rd Kent IL
61044-9605 OPR FR, OF HP 11/26/2012 OAI Y
9367 3008575486 Rocky Ford Pet Foods 21693 Highway 50 East Rocky Ford CO
81067 OPR RE, TH HP 2/27/2013 OAI N
9446 DEN-DO 1713202 Weld County Bi Products, Inc. 1138 N 11th Ave Greeley
CO 80631-9501 OPR RE, TH HP 10/12/2012 OAI N
9447 DEN-DO 3002857110 Weld County Bi-Products dba Fort Morgan Pet Foods
13553 County Road 19 Fort Morgan CO 80701-7506 OPR RE HP 12/7/2011 OAI N
see full list of the fda mad cow bse feed follies, toward the bottom,
after a short brief update on the mad cow bse follies, and our good friend
Lester Crawford that was at the FDA.
ALSO, I would kindly like to comment on this FDA BSE/Ruminant Feed
Inspections Firms Inventory (excel format)4 format, for reporting these breaches
of BSE TSE prion protocols, from the extensive mad cow feed ban warning letters
the fda use to put out for each violations. simply put, this excel format sucks,
and the FDA et al intentionally made it this difficult to follow the usda fda
mad cow follies. this is an intentional format to make it as difficult as
possible to follow these breaches of the mad cow TSE prion safety feed
protocols. to have absolutely no chronological or numerical order, and to format
such violations in a way that they are almost impossible to find, says a lot
about just how far the FDA and our fine federal friends will go through to hide
these continued violations of the BSE TSE prion mad cow feed ban, and any
breaches of protocols there from. once again, the wolf guarding the henhouse $$$
NAI = NO ACTION INDICATED
OAI = OFFICIAL ACTION INDICATED
VAI = VOLUNTARY ACTION INDICATED
RTS = REFERRED TO STATE
Inspections conducted by State and FDA investigators are classified to
reflect the compliance status at the time of the inspection, based upon whether
objectionable conditions were documented. Based on the conditions found,
inspection results are recorded in one of three classifications:
OAI (Official Action Indicated) when inspectors find significant
objectionable conditions or practices and believe that regulatory sanctions are
warranted to address the establishment’s lack of compliance with the regulation.
An example of an OAI classification would be findings of manufacturing
procedures insufficient to ensure that ruminant feed is not contaminated with
prohibited material. Inspectors will promptly re-inspect facilities classified
OAI after regulatory sanctions have been applied to determine whether the
corrective actions are adequate to address the objectionable conditions.
VAI (Voluntary Action Indicated) when inspectors find objectionable
conditions or practices that do not meet the threshold of regulatory
significance, but warrant an advisory to inform the establishment that
inspectors found conditions or practices that should be voluntarily corrected.
VAI violations are typically technical violations of the 1997 BSE Feed Rule.
These violations include minor recordkeeping lapses or conditions involving
non-ruminant feeds.
NAI (No Action Indicated) when inspectors find no objectionable conditions
or practices or, if they find objectionable conditions, those conditions are of
a minor nature and do not justify further actions.
when sound science was bought off by junk science, in regards to the BSE
TSE prion mad cow type disease, by the USDA, CFIA, WHO, OIE, et al. $$$
when the infamous, and fraudulently USDA, FSIS, APHIS, FDA, gold card was
taken away that infamous day in December of 2003, all cards were off the table,
it was time to change the science, and change they did. ...tss
snip. ...please see full text ;
Thursday, June 6, 2013
BSE TSE PRION USDA FDA MAD COW FEED COMPLIANCE REPORT and NAI, OAI, and
VAI ratings as at June 5, 2013
IN A NUT SHELL ;
(Adopted by the International Committee of the OIE on 23 May 2006)
11. Information published by the OIE is derived from appropriate
declarations made by the official Veterinary Services of Member Countries. The
OIE is not responsible for inaccurate publication of country disease status
based on inaccurate information or changes in epidemiological status or other
significant events that were not promptly reported to the Central Bureau,
Sunday, December 15, 2013
*** FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED
VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2013 UPDATE
Saturday, November 10, 2012
Wisconsin Firm Recalls Beef Tongues That May Contain Specified Risk
Materials Nov 9, 2012 WI Firm Recalls Beef Tongues
Saturday, July 23, 2011
CATTLE HEADS WITH TONSILS, BEEF TONGUES, SPINAL CORD, SPECIFIED RISK
MATERIALS (SRM's) AND PRIONS, AKA MAD COW DISEASE
Sunday, October 18, 2009
Wisconsin Firm Recalls Beef Tongues That Contain Prohibited Materials SRM
WASHINGTON, October 17, 2009
Thursday, October 15, 2009
Nebraska Firm Recalls Beef Tongues That Contain Prohibited Materials SRM
WASHINGTON, Oct 15, 2009
Thursday, June 26, 2008
Texas Firm Recalls Cattle Heads That Contain Prohibited Materials
Tuesday, July 1, 2008
Missouri Firm Recalls Cattle Heads That Contain Prohibited Materials SRMs
Friday, August 8, 2008
Texas Firm Recalls Cattle Heads That Contain Prohibited Materials SRMs
941,271 pounds with tonsils not completely removed
Saturday, April 5, 2008
SRM MAD COW RECALL 406 THOUSAND POUNDS CATTLE HEADS WITH TONSILS KANSAS
Wednesday, April 30, 2008
Consumption of beef tongue: Human BSE risk associated with exposure to
lymphoid tissue in bovine tongue in consideration of new research findings
Wednesday, April 30, 2008
Consumption of beef tongue: Human BSE risk associated with exposure to
lymphoid tissue in bovine tongue in consideration of new research findings
Friday, October 15, 2010
BSE infectivity in the absence of detectable PrPSc accumulation in the
tongue and nasal mucosa of terminally diseased cattle
SPECIFIED RISK MATERIALS SRMs
2007
10,000,000+ LBS. of PROHIBITED BANNED MAD COW FEED I.E. BLOOD LACED MBM IN
COMMERCE USA 2007
Date: March 21, 2007 at 2:27 pm PST
RECALLS AND FIELD CORRECTIONS: VETERINARY MEDICINES -- CLASS II
PRODUCT
Bulk cattle feed made with recalled Darling's 85% Blood Meal, Flash Dried,
Recall # V-024-2007
CODE
Cattle feed delivered between 01/12/2007 and 01/26/2007
RECALLING FIRM/MANUFACTURER
Pfeiffer, Arno, Inc, Greenbush, WI. by conversation on February 5, 2007.
Firm initiated recall is ongoing.
REASON
Blood meal used to make cattle feed was recalled because it was cross-
contaminated with prohibited bovine meat and bone meal that had been
manufactured on common equipment and labeling did not bear cautionary BSE
statement.
VOLUME OF PRODUCT IN COMMERCE
42,090 lbs.
DISTRIBUTION
WI
___________________________________
PRODUCT
Custom dairy premix products:
MNM ALL PURPOSE Pellet, HILLSIDE/CDL Prot- Buffer Meal, LEE, M.-CLOSE UP
PX Pellet, HIGH DESERT/ GHC LACT Meal, TATARKA, M CUST PROT Meal, SUNRIDGE/CDL
PROTEIN Blend, LOURENZO, K PVM DAIRY Meal, DOUBLE B DAIRY/GHC LAC Mineral, WEST
PIONT/GHC CLOSEUP Mineral, WEST POINT/GHC LACT Meal, JENKS, J/COMPASS PROTEIN
Meal, COPPINI - 8# SPECIAL DAIRY Mix, GULICK, L-LACT Meal (Bulk), TRIPLE J -
PROTEIN/LACTATION, ROCK CREEK/GHC MILK Mineral, BETTENCOURT/GHC S.SIDE MK-MN,
BETTENCOURT #1/GHC MILK MINR, V&C DAIRY/GHC LACT Meal, VEENSTRA, F/GHC LACT
Meal, SMUTNY, A- BYPASS ML W/SMARTA, Recall # V-025-2007
CODE
The firm does not utilize a code - only shipping documentation with
commodity and weights identified.
RECALLING FIRM/MANUFACTURER
Rangen, Inc, Buhl, ID, by letters on February 13 and 14, 2007. Firm
initiated recall is complete.
REASON
Products manufactured from bulk feed containing blood meal that was cross
contaminated with prohibited meat and bone meal and the labeling did not bear
cautionary BSE statement.
VOLUME OF PRODUCT IN COMMERCE
9,997,976 lbs.
DISTRIBUTION
ID and NV
END OF ENFORCEMENT REPORT FOR MARCH 21, 2007
Saturday, August 4, 2012
Final Feed Investigation Summary - California BSE Case - July 2012
Saturday, August 4, 2012
Update from APHIS Regarding Release of the Final Report on the BSE
Epidemiological Investigation
Wednesday, September 25, 2013
Inspections, Compliance, Enforcement, and Criminal Investigations BSE TSE
PRION 2013
Wednesday, October 30, 2013
SPECIFIED RISK MATERIAL (SRM) CONTROL VERIFICATION TASK FSIS NOTICE 70-13
10/30/13
Owens, Julie
From: Terry S. Singeltary Sr. [flounder9@verizon.net]
Sent: Monday, July 24, 2006 1:09 PM
To: FSIS RegulationsComments
Subject: [Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of
Bovine Spongiform Encephalopathy (BSE) Page 1 of 98
FSIS, USDA, REPLY TO SINGELTARY
2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006
remember, the sporadic cjd i.e. 85%+ of all human tse prion disease, has
now been linked to ;
-------- Original Message --------
Subject: re-BSE prions propagate as either variant CJD-like or sporadic CJD
Date: Thu, 28 Nov 2002 10:23:43 -0000
From: "Asante, Emmanuel A" e.asante@ic.ac.uk
To: "'flounder@wt.net'" flounder@wt.net
Dear Terry,
I have been asked by Professor Collinge to respond to your request. I am a
Senior Scientist in the MRC Prion Unit and the lead author on the paper. I have
attached a pdf copy of the paper for your attention.
Thank you for your interest in the paper.
In respect of your first question, the simple answer is, ***yes. As you
will find in the paper, we have managed to associate the alternate phenotype to
type 2 PrPSc, the commonest sporadic CJD. It is too early to be able to claim
any further sub-classification in respect of Heidenhain variant CJD or Vicky
Rimmer's version. It will take further studies, which are on-going, to establish
if there are sub-types to our initial finding which we are now reporting. The
main point of the paper is that, as well as leading to the expected new variant
CJD phenotype, BSE transmission to the 129-methionine genotype can lead to an
alternate phenotype which is indistinguishable from type 2 PrPSc.
I hope reading the paper will enlighten you more on the subject. If I can
be of any further assistance please to not hesitate to ask. Best wishes.
Emmanuel Asante
<>
____________________________________
Dr. Emmanuel A Asante MRC Prion Unit & Neurogenetics Dept. Imperial
College School of Medicine (St. Mary's) Norfolk Place, LONDON W2 1PG Tel: +44
(0)20 7594 3794 Fax: +44 (0)20 7706 3272 email: e.asante@ic.ac.uk (until
9/12/02) New e-mail: e.asante@prion.ucl.ac.uk (active from now)
____________________________________
Thursday, August 12, 2010
Seven main threats for the future linked to prions
First threat
The TSE road map defining the evolution of European policy for protection
against prion diseases is based on a certain numbers of hypotheses some of which
may turn out to be erroneous. In particular, a form of BSE (called atypical
Bovine Spongiform Encephalopathy), recently identified by systematic testing in
aged cattle without clinical signs, may be the origin of classical BSE and thus
potentially constitute a reservoir, which may be impossible to eradicate if a
sporadic origin is confirmed.
***Also, a link is suspected between atypical BSE and some apparently
sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases
constitute an unforeseen first threat that could sharply modify the European
approach to prion diseases.
Second threat
snip...
Monday, October 10, 2011
EFSA Journal 2011 The European Response to BSE: A Success Story
snip...
EFSA and the European Centre for Disease Prevention and Control (ECDC)
recently delivered a scientific opinion on any possible epidemiological or
molecular association between TSEs in animals and humans (EFSA Panel on
Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical
BSE prions as the only TSE agents demonstrated to be zoonotic so far
*** but the possibility that a small proportion of human cases so far
classified as "sporadic" CJD are of zoonotic origin could not be excluded.
Moreover, transmission experiments to non-human primates suggest that some TSE
agents in addition to Classical BSE prions in cattle (namely L-type Atypical
BSE, Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic
wasting disease (CWD) agents) might have zoonotic potential.
snip...
To date the OIE/WAHO assumes that the human and animal health standards set
out in the BSE chapter for classical BSE (C-Type) applies to all forms of BSE
which include the H-type and L-type atypical forms. This assumption is
scientifically not completely justified and accumulating evidence suggests that
this may in fact not be the case. Molecular characterization and the spatial
distribution pattern of histopathologic lesions and immunohistochemistry (IHC)
signals are used to identify and characterize atypical BSE. Both the L-type and
H-type atypical cases display significant differences in the conformation and
spatial accumulation of the disease associated prion protein (PrPSc) in brains
of afflicted cattle. Transmission studies in bovine transgenic and wild type
mouse models support that the atypical BSE types might be unique strains because
they have different incubation times and lesion profiles when compared to C-type
BSE. When L-type BSE was inoculated into ovine transgenic mice and Syrian
hamster the resulting molecular fingerprint had changed, either in the first or
a subsequent passage, from L-type into C-type BSE.
***In addition, non-human primates are specifically susceptible for
atypical BSE as demonstrated by an approximately 50% shortened incubation time
for L-type BSE as compared to C-type. Considering the current scientific
information available, it cannot be assumed that these different BSE types pose
the same human health risks as C-type BSE or that these risks are mitigated by
the same protective measures.
Monday, May 19, 2014
*** Variant CJD: 18 years of research and surveillance
Discussion: The C, L and H type BSE cases in Canada exhibit molecular
characteristics similar to those described for classical and atypical BSE cases
from Europe and Japan. *** This supports the theory that the importation of BSE
contaminated feedstuff is the source of C-type BSE in Canada. *** It also
suggests a similar cause or source for atypical BSE in these countries. ***
see page 176 of 201 pages...tss
*** Singeltary reply ; Molecular, Biochemical and Genetic Characteristics
of BSE in Canada Singeltary reply ;
Sunday, November 13, 2011
*** California BSE mad cow beef recall, QFC, CJD, and dead stock downer
livestock
Mad cow disease: Could it be here?
Man's stubborn crusade attracts experts' notice By Carol Christian | August
5, 2001
yes, cjd is popping up in more and more places it seems. I think in 55 year
and older, it's now 1 in 9,000.
see ;
lifetime risk of developing sporadic CJD is about 1 in 30,000, jumps to 1
in 9,000 in 50 years of age and above
IN REALITY, sporadic CJD is 1 in 9,000 in 50 years of age and above, and
that's with a inadequate or what I call passive surveillance system. see below
;
Dr. William Shulaw, a veterinarian with The Ohio State University extension
service, is involved in a nationwide program to eradicate scrapie, the form of
BSE found in sheep.
Shulaw said the chances of a person getting sporadic Creutzfeldt- Jakob
disease is about one in a million. But that's the total population, infants,
children, adults and the elderly.
Chances increase to one in 9,000 when the group is restricted to those age
50 and older.
Tuesday, March 11, 2014
Science and Technology Committee Oral evidence: Blood, tissue and organ
screening, HC 990 Wednesday 5 March 2014 SPORADIC CJD
Actually, it is nearer 2 per million per year of the population will
develop sporadic CJD, but your lifetime risk of developing sporadic CJD is about
1 in 30,000. So that has not really changed. When people talk about 1 per
million, often they interpret that as thinking it is incredibly rare. They think
they have a 1-in-a-million chance of developing this disease. You haven’t.
You’ve got about a 1-in-30,000 chance of developing it.
USA 2007-2008 sporadic CJD statistics revised to 1 in 9,000 in ages 55 and
older !
The statistical incidence of CJD cases in the United States has been
revised to reflect that there is one case per 9000 in adults age 55 and older.
Eighty-five percent of the cases are sporadic, meaning there is no known cause
at present.
but, the real count on sporadic CJD TSE human prion is not
known...tss
Friday, April 25, 2014
Accuracy of administrative diagnostic data for pathologically confirmed
cases of Creutzfeldt-Jakob disease
Creutzfeldt-Jakob Disease CJD cases rising North America updated report
August 2013
*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada
seeing an extreme increase of 48% between 2008 and 2010 ***
Sunday, October 13, 2013
*** CJD TSE Prion Disease Cases in Texas by Year, 2003-2012
Tuesday, April 01, 2014
Questions linger in U.S. CJD cases 2005, and still do in 2014
layperson
just made a promise to mom, never forget, never let them forget...dod
12/14/97 confirmed hvCJD TSE prion disease...
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518
